All configurationsSome configurationsNoneNot reported by EPA
Configurations by year
2027 Mercedes-Benz S-Class
4 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
Maybach S680 4matic
6.0L 12-cyl turbo
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S500 4matic
3.0L 6-cyl turbo supercharged hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic Maybach
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
2026 Mercedes-Benz S-Class
4 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
Maybach S680 4matic
6.0L 12-cyl turbo
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S500 4matic
3.0L 6-cyl turbo supercharged hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic Maybach
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
2025 Mercedes-Benz S-Class
6 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
AMG S63 E Performance
4.0L 8-cyl turbo plug-in hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
Maybach S680 4matic
6.0L 12-cyl turbo
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S500 4matic
3.0L 6-cyl turbo supercharged hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic Maybach
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580e 4matic
3.0L 6-cyl turbo plug-in hybrid
9-speed automatic9-spd
All-Wheel
No
Premium
No
2024 Mercedes-Benz S-Class
4 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
Maybach S680 4matic
6.0L 12-cyl turbo
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S500 4matic
3.0L 6-cyl turbo supercharged hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic Maybach
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
2023 Mercedes-Benz S-Class
5 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
Maybach S680 4matic
6.0L 12-cyl turbo
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S500 4matic
3.0L 6-cyl hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic Maybach
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580e 4matic
3.0L 6-cyl turbo plug-in hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
2022 Mercedes-Benz S-Class
4 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
Maybach S680 4matic
6.0L 12-cyl turbo
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S500 4matic
3.0L 6-cyl hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
S580 4matic Maybach
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
All-Wheel
Yes
Premium
No
2021 Mercedes-Benz S-Class
7 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
AMG S63 4matic Plus Convertible
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
AMG S63 4matic Plus Coupe
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S500 4matic
3.0L 6-cyl hybrid
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560 4matic Coupe
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560 Convertible
4.0L 8-cyl turbo
9-speed automatic9-spd
Rear-Wheel
Yes
Premium
No
S580 4matic
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S580 4matic Maybach
4.0L 8-cyl turbo hybrid
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
2020 Mercedes-Benz S-Class
13 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
AMG S63 4matic Plus
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
AMG S63 4matic Plus Convertible
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
AMG S63 4matic Plus Coupe
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
AMG S65
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
Maybach S650
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S450
3.0L 6-cyl turbo
9-speed automatic9-spd
Rear-Wheel
Yes
Premium
No
S450 4matic
3.0L 6-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560
4.0L 8-cyl turbo
9-speed automatic9-spd
Rear-Wheel
Yes
Premium
No
S560 4matic
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560 4matic Coupe
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560 4matic Maybach
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560 Convertible
4.0L 8-cyl turbo
9-speed automatic9-spd
Rear-Wheel
Yes
Premium
No
S560e
3.0L 6-cyl turbo plug-in hybrid
9-speed automatic9-spd
Rear-Wheel
Yes
Premium
No
2019 Mercedes-Benz S-Class
15 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
AMG S63 4matic
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
AMG S63 4matic Convertible
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
AMG S63 4matic Coupe
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
AMG S65
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
AMG S65 Convertible
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
AMG S65 Coupe
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
Maybach S560 4matic
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
Maybach S650
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S450
3.0L 6-cyl turbo
9-speed automatic9-spd
Rear-Wheel
Yes
Premium
No
S450 4matic
3.0L 6-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560
4.0L 8-cyl turbo
9-speed automatic9-spd
Front-Wheel
Yes
Premium
No
S560 4matic
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560 4matic Coupe
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560 Convertible
4.0L 8-cyl turbo
9-speed automatic9-spd
Front-Wheel
Yes
Premium
No
S560e
3.0L 4-cyl turbo plug-in hybrid
9-speed automatic9-spd
Rear-Wheel
Yes
Premium
No
2018 Mercedes-Benz S-Class
14 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
AMG S63 4matic
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
AMG S63 4matic Convertible
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
AMG S63 4matic Coupe
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
AMG S65
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
AMG S65 Convertible
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
AMG S65 Coupe
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
Maybach S560 4matic
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
Maybach S650
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S450
3.0L 6-cyl turbo
9-speed automatic9-spd
Rear-Wheel
Yes
Premium
No
S450 4matic
3.0L 6-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560
4.0L 8-cyl turbo
9-speed automatic9-spd
Front-Wheel
Yes
Premium
No
S560 4matic
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560 4matic Coupe
4.0L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S560 Convertible
4.0L 8-cyl turbo
9-speed automatic9-spd
Front-Wheel
Yes
Premium
No
2017 Mercedes-Benz S-Class
12 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
AMG S63 4matic
5.5L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
AMG S63 4matic Convertible
5.5L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
AMG S63 4matic Coupe
5.5L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
AMG S65
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S550
4.7L 8-cyl turbo
9-speed automatic9-spd
Rear-Wheel
Yes
Premium
No
S550 4matic
4.7L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S550 4matic Coupe
4.7L 8-cyl turbo
9-speed automatic9-spd
4-Wheel
Yes
Premium
No
S550 Convertible
4.7L 8-cyl turbo
9-speed automatic9-spd
Rear-Wheel
Yes
Premium
No
S550e
3.0L 6-cyl turbo plug-in hybrid
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S600
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S65 AMG Convertible
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S65 AMG Coupe
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
2016 Mercedes-Benz S-Class
9 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
AMG S63 4matic
5.5L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
AMG S63 4matic Coupe
5.5L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
AMG S65
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
AMG S65 Coupe
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S550
4.7L 8-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S550 4matic
4.7L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
S550 4matic Coupe
4.7L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
S550e
3.0L 6-cyl turbo plug-in hybrid
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S600
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
2015 Mercedes-Benz S-Class
9 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
S550
4.7L 8-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S550 4matic
4.7L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
S550 4matic Coupe
4.7L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
S550e
3.0L 6-cyl turbo plug-in hybrid
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S600
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S63 AMG 4matic
5.5L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
S63 AMG 4matic Coupe
5.5L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
S65 AMG
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S65 AMG Coupe
6.0L 12-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
2014 Mercedes-Benz S-Class
3 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
S550
4.7L 8-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S550 4matic
4.7L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
S63 AMG 4matic
5.5L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Yes
Premium
No
2013 Mercedes-Benz S-Class
6 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
S400 Hybrid
3.5L 6-cyl hybrid
7-speed automatic7-spd
Rear-Wheel
Yes
Premium
No
S550
4.7L 8-cyl turbo
7-speed automatic7-spd
Rear-Wheel
No
Premium
No
S550 4matic
4.7L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
No
Premium
No
S600
5.5L 12-cyl turbo
5-speed automatic5-spd
Rear-Wheel
No
Premium
No
S63 AMG
5.5L 8-cyl turbo
7-speed automatic7-spd
Rear-Wheel
No
Premium
No
S65 AMG
6.0L 12-cyl turbo
5-speed automatic5-spd
Rear-Wheel
No
Premium
No
2012 Mercedes-Benz S-Class
6 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
S400 Hybrid
3.5L 6-cyl hybrid
7-speed automatic7-spd
Rear-Wheel
Not reported
Premium
No
S550
4.7L 8-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Not reported
Premium
No
S550 4matic
4.7L 8-cyl turbo
7-speed automatic7-spd
4-Wheel
Not reported
Premium
No
S600
5.5L 12-cyl turbo
5-speed automatic5-spd
Rear-Wheel
Not reported
Premium
No
S63 AMG
5.5L 8-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Not reported
Premium
No
S65 AMG
6.0L 12-cyl turbo
5-speed automatic5-spd
Rear-Wheel
Not reported
Premium
No
2011 Mercedes-Benz S-Class
6 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
S400 Hybrid
3.5L 6-cyl hybrid
7-speed automatic7-spd
Rear-Wheel
Not reported
Premium
No
S550
5.5L 8-cyl
7-speed automatic7-spd
Rear-Wheel
Not reported
Premium
No
S550 4matic
5.5L 8-cyl
7-speed automatic7-spd
4-Wheel
Not reported
Premium
No
S600
5.5L 12-cyl turbo
5-speed automatic5-spd
Rear-Wheel
Not reported
Premium
No
S63 AMG
5.5L 8-cyl turbo
7-speed automatic7-spd
Rear-Wheel
Not reported
Premium
No
S65 AMG
6.0L 12-cyl turbo
5-speed automatic5-spd
Rear-Wheel
Not reported
Premium
No
2010 Mercedes-Benz S-Class
6 configurations
EPA model name
Engine
Transmission
Drive
Start-stop
EPA test fuel
Flex-fuel
S400 Hybrid
3.5L 6-cyl hybrid
7-speed automatic7-spd
Rear-Wheel
Not reported
Premium
No
S550
5.5L 8-cyl
7-speed automatic7-spd
Rear-Wheel
Not reported
Premium
No
S550 4matic
5.5L 8-cyl
7-speed automatic7-spd
4-Wheel
Not reported
Premium
No
S600
5.5L 12-cyl turbo
5-speed automatic5-spd
Rear-Wheel
Not reported
Premium
No
S63 AMG
6.3L 8-cyl
7-speed automatic7-spd
Rear-Wheel
Not reported
Premium
No
S65 AMG
6.0L 12-cyl turbo
5-speed automatic5-spd
Rear-Wheel
Not reported
Premium
No
Check before you buy or refuel Confirm on the window sticker, owner's manual or with the dealer. Trims and options can differ from the configurations EPA tested.
About premium fuel EPA data shows the fuel a vehicle was tested on. It does not say whether premium is required or only recommended. Your owner's manual or fuel-door label is the authority.
Before using E85 Confirm the vehicle is a flex-fuel vehicle (FFV) in the owner's manual, or look for a yellow gas cap or an "FFV" badge. Not every version of a model is flex-fuel.